American Society of Gene Therapy


	Final Program ASGT 9th Annual Meeting May 31 - June 4, 2006 Baltimore Convention Center · Baltimore, MD · USA
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Program Schedule

(This program is subject to updates/changes.)

Saturday, June 3

Scientific Symposium 400
8:00 am - 10:00 am
Cancer: Cancer Gene Therapy
Room: Ballroom
Chair: John C. Morris, MD

Speakers:
Mark E. Davis, PhD
Size Matters for Systemic Delivery

Paul B. Fisher, MPH, PhD
Melanoma Differentiation Associated Gene-7 (MDA-7)/IL-24: A ‘Magic Bullet’ for Cancer?

Michel Sadelain, MD, PhD
Targeting Systemic Tumors with Genetically Enhanced T Lymphocytes

Scientific Symposium 401
8:00 am - 10:00 am
Cardiovascular: Modulating Cardiac Phenotype: From Basic Mechanism to Clinical Trials
Room: 316/317
Chair: Gabor M. Rubanyi, MD, PhD

Speakers:
Eduardo Marban, MD, PhD
Gene Therapy for Cardiac Arrhythmias

Loren Field, PhD
Cyclins as Therapeutic Targets

Timothy D. Henry, MD
Lessons Learned from AGENT 3-4 Trials

Scientific Symposium 402
8:00 am - 10:00 am
Ethics: Ethics of Gene Therapy/Biodefense Research
Room: 318/320
Chair: Jonathan Kimmelman, PhD

Speakers:
Ronald G. Crystal, MD
Genetic Medicines for Biodefense

Samuel Kaplan, PhD
Publication of Biodefense Research Results: Ethical Issues

Ronald M. Atlas, PhD
Ethics and Public Policy in Biodefense Research

Scientific Symposium 403
8:00 am - 10:00 am
Musculo-Skeletal: Systemic Gene Delivery in Large Animals
Room: 314/315
Chair: Dongsheng Duan, PhD

Speakers:
Hansell H. Stedman, MD
From Regional to Systemic Gene Delivery in the Large Animal Model

Luis Garcia
Exon-skipping Gene Therapy for DMD Mediated by AAV(U7): From Proof of Concept to Proof of Practicability in Large Animals

Annemieke Aartsma-Rus
First-in-Man Study on Antisense-Induced Exon Skipping for Duchenne Muscular Dystrophy

Scientific Symposium 404
8:00 am - 10:00 am
Oligonucleotide Based Therapies: Repairing Genetic Information
Room: 327/329
Chair: Peter Glazer, MD, PhD

Speakers:
Ryszard Kole, PhD
Correcting Splicing Signal Defects with Antisense Oligonucleotide

Alan Lambowitz, PhD
Gene Targeting Using Group II Introns ("Targetrons")

Matthew H. Porteus, MD, PhD
Using Zinc Finger Nucleuses to Stimulate Homologous Recombination

Scientific Symposium 405
8:00 am - 10:00 am
Special: Neurobehavior Symposium
Room: 339/342
Chair: Inder Verma, PhD

Speakers:
Carrolee Barlow, MD, PhD
Glyoxalase 1 and Glutathione Reductase 1 Regulate Anxiety in Mice

John Neumaier, MD PhD
Sorting Out Serotonin with Viral Gene Transfer

Larry Young, PhD
Manipulating Social Behavior with Viral Vectors

Break
10:00 am - 10:15 am

Simultaneous Oral Abstract Sessions
10:15 am – 12:15 am

Oral Abstract Session 410
Clinical Gene Therapy
Room: 339/342
Moderators: Steven M. Albelda, MD and Arthur W. Nienhuis, MD
(Abstracts #723 - #730)

Oral Abstract Session 411
RNA Virus Vectors II: Integration and Efficacy
Room: 327/329
Moderator: Christof von Kalle, MD and Isabelle Riviere, PhD
(Abstracts #731 - #738)

Oral Abstract Session 412
AAV Vector Development
Room: 314/315
Moderators: Arun Srivastava, PhD, and Guang-ping Gao, PhD
(Abstracts #739 - #746)

Oral Abstract Session 413
Physical Methods of Delivery
Room: 345/346
Moderators: Ronald K. Scheule, PhD and James E. Hagstrom, PhD
(Abstracts #747 - #754)

Oral Abstract Session 414
Gene Therapy for HIV & AIDS
Room: 337/338
Moderators: Bruce E. Torbett, PhD, MSPH and David Strayer, MD, PhD
(Abstracts #755 - #762)

Oral Abstract Session 415
Cancer-Immunotherapy: Lymphocyte Targets for Gene Therapy
Room: 318/320
Moderators: Richard Morgan, PhD, and Renier J. Brentjens, MD, PhD
(Abstracts #763 - #770)

Oral Abstract Session 416
Cancer-Targeted Gene Therapy: Preclinical Studies II
Room: 316/317
Moderator: Rajagopal Ramesh, PhD
(Abstracts #771 - #778)

Oral Abstract Session 417
Lung and Respiratory Disease
Room: 343/344
Moderator: Deborah Gill, PhD
(Abstracts #779 - #786)

Oral Abstract Session 418
Gene Expression and New Methods
Room: 324/326
Moderators: Christopher Baum, MD and Punam Malik, MD
(Abstracts #787 - #794)

Oral Abstract Session 419
Oligonucleotide Therapies: Viral Targets
Room: 321/323
Moderators: Anton P. McCaffrey, PhD and Barry Polisky, PhD
(Abstracts #795 - #802)

Meet-the-Investigator Lunch 420
12:30 pm - 1:30 pm
Room: 347
Speaker:
Pedro Lowenstein, MD, PhD
Making Gene Therapy Work in Spite of Adverse Immune Responses: New Vectors, Transgenes, and Clinical Trial Designs

Meet-the-Investigator Lunch 421
12:30 pm - 1:30 pm
Room: 348
Speakers:
John F. Engelhardt, PhD and Gerard McGarrity, PhD
Choosing a Career: Academics versus Biotech

Presidential Symposium 430
2:00 pm - 5:00 pm

Presidential Symposium

Room: Ballroom

Chair:
Mark A. Kay, MD, PhD

Speaker:
Joseph Sodroski, MD
Post-Entry, Species-Specific Barriers to Retroviral Infection

And Presentation of Top Abstracts

#803 - Brian D. Brown, PhD - Endogenous microRNA Regulation Suppresses Transgene Expression in Hematopoietic Lineages and Enables Stable Gene Transfer

#804 - Karsten Wursthorn, MD - In Vivo Correction of a Metabolic Liver Disease by AAV8-Mediated Homologous Recombination

#805 - Dirk Grimm, PhD - Fatality in Mice Due to Oversaturation of Cellular Micro/Short Hairpin RNA Pathways

#806 - Javier Chinen, MD, PhD - Immunologic Improvement after Gene Therapy in 3 Preadolescents with X-Linked Severe Combined Immunodeficiency (XSCID)

#807 - Liang N. Zhang, MD - NADPH-Dependent Endosomal ROS Is Critical for rAAV Capsid Processing during Infection

Presentation of the top 5 abstracts
(Abstracts #803 - #807)

Poster Session III
5:00 pm - 7:00 pm

RNA Virus Vectors II
(Abstracts 808 through 831)

Adenoviral Vectors: Clinical Applications
(Abstracts 832 through 854; Abstract 837 has been moved to Poster Session I)

Immunodeficiencies/Hemophilia
(Abstracts 855 through 864)

Gene Therapy for Vascular Disease
(Abstracts 865 through 880)

Neurologic: Applications to Brain and Eye; Vector Development; Immune Responses
(Abstracts 881 through 905)

Muscle and Connective Tissue II
(Abstracts 906 through 921)

Cancer-Apoptosis and Suicide
(Abstracts 922 through 947)

Cancer-Targeted Gene Therapy: Other Viruses and New Approaches
(Abstracts 948 through 973)

Vector and Transgene Immunology
(Abstracts 974 through 999)

Gene Expression II
(Abstracts 1000 through 1018)

Oligonucleotide Therapies B
(Abstracts 1019 through 1039)

Stem Cell Gene Therapy
(Abstracts 1040 through 1055)